Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | HPD | P32754 | 4/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | GSR | P00390 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GRM5 | P41594 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | TDO2 | P48775 | 1/20 | 0.50 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29110427 | 0.88 | POLB (0.73) | POLBNPC1HRH3KCNH2HPD | |
| SCHEMBL30089869 | 0.88 | POLB (0.73) | POLBNPC1HRH3KCNH2HPD | |
| SCHEMBL22238067 | 0.87 | POLB (0.72) | POLBHRH3KCNH2HPDL3MBTL1 | |
| SCHEMBL31196714 | 0.87 | POLB (0.61) | POLBNPC1HRH3KCNH2HPD | |
| SCHEMBL30149472 | 0.86 | POLB (0.71) | POLBNPC1HRH3KCNH2HPD | |
| SCHEMBL28924646 | 0.86 | POLB (0.71) | POLBNPC1HRH3KCNH2HPD | |
| SCHEMBL31196718 | 0.84 | HPD (0.61) | POLBNPC1HRH3KCNH2HPD | |
| SCHEMBL31463104 | 0.82 | NPC1 (0.71) | POLBNPC1HRH3KCNH2HPD | |
| SCHEMBL18332822 | 0.82 | POLB (0.65) | POLBHRH3KCNH2HPDL3MBTL1 | |
| SCHEMBL15302024 | 0.82 | NPC1 (0.70) | POLBNPC1HRH3KCNH2HPD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934934-A2 | Methods of preparing substituted 3-phenyl- and 3-pyridyl-4(3H)-quinazolinones and atropisomers thereof | Pfizer Products Inc. (US) | 1999-08-11 | — | — | EP | disclosed |