SCHEMBL8307825

SCHEMBL8307825

CCCC[Si](C)(C)OCCC(CN(C)C(=O)c1cc(OC)c(OC)c(OC)c1)c1ccc(C)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.39
SLC6A5 Q9Y345 4/20 0.36
KMT2A Q03164 3/20 0.36
NPC1 O15118 1/20 0.34
GLA P06280 1/20 0.34
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HPGD P15428 1/20 0.33
UBE2N P61088 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
HSD17B10 Q99714 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
THPO P40225 1/20 0.33
MTOR P42345 1/20 0.33
MEN1 O00255 1/20 0.33
PMP22 Q01453 1/20 0.33
SCN1A P35498 1/20 0.33
SCN2A Q99250 1/20 0.33
SCN3A Q9NY46 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8308170 0.89 TACR2 (0.42) TACR1
SCHEMBL6594635 0.85 L3MBTL1 (0.39) L3MBTL1KMT2ASCN1ASCN2ASCN3A
SCHEMBL6596199 0.81 L3MBTL1 (0.43) L3MBTL1KMT2AKDM4EALDH1A1MEN1
SCHEMBL6596708 0.78 L3MBTL1 (0.40) L3MBTL1KMT2AKDM4EALDH1A1TACR1
SCHEMBL6592845 0.74 TACR2 (0.44) TACR1
SCHEMBL6595659 0.73 TP53 (0.39) KMT2AALDH1A1SMN1; SMN2CYP3A4MEN1
SCHEMBL6597619 0.73 TXNRD1 (0.38) L3MBTL1KMT2AKDM4EALDH1A1SMN1; SMN2
SCHEMBL6596380 0.73 TACR1 (0.40) L3MBTL1SLC6A5KMT2AALDH1A1SMN1; SMN2
SCHEMBL6600716 0.71 TDP1 (0.40) KMT2AALDH1A1MEN1TACR1
SCHEMBL6595005 0.71 TACR2 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0888338-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL) 1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1999-01-07 EP disclosed
WO-1997030991-A1 NOVEL SUBSTITUTED N-METHYL-N-(4-(4-(1H-BENZIMIDAZOL-2-YL)[1,4]DIAZEPAN-1-YL)-2-(ARYL)BUTYL)BENZAMIDES USEFUL FOR THE TREATMENT OF ALLERGIC DISEASES HOECHST MARION ROUSSEL, INC. (US) 1997-08-28 WO disclosed