Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17922967 | 0.88 | MEN1 (0.45) | CYP11B1CYP11B2HRH4HRH3CYP1A2 | |
| SCHEMBL14257669 | 0.86 | CYP1A2 (0.56) | CYP11B1CYP11B2HRH4HRH3CYP1A2 | |
| SCHEMBL8309349 | 0.84 | TBXAS1 (0.51) | CYP11B1CYP11B2CYP1A2CYP2D6TBXAS1 | |
| SCHEMBL727185 | 0.83 | CYP1A2 (0.62) | CYP11B1CYP11B2HRH4HRH3CYP1A2 | |
| SCHEMBL1773262 | 0.82 | TBXAS1 (0.56) | CYP11B1CYP11B2HRH4HRH3CYP1A2 | |
| SCHEMBL7384351 | 0.80 | CYP1A2 (0.43) | CYP1A2CYP2D6CHRNA7CHRNB2CHRNA4 | |
| SCHEMBL17670548 | 0.79 | CYP2A6 (0.46) | CYP11B1CYP11B2HRH4HRH3CYP1A2 | |
| SCHEMBL29995759 | 0.77 | CYP11B1 (0.65) | CYP11B1CYP11B2HRH4HRH3CYP1A2 | |
| SCHEMBL177863 | 0.77 | CYP11B1 (0.65) | CYP11B1CYP11B2HRH4HRH3CYP1A2 | |
| SCHEMBL22131463 | 0.77 | CYP11B1 (0.47) | CYP11B1CYP11B2HRH4HRH3CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0579618-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | Pfizer Limited (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017451-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LIMITED (GB) | 1992-10-15 | — | — | WO | disclosed |