Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307942 | 0.79 | CYP11B1 (0.47) | CHRNA7HRH4HRH3CYP1A2CYP2D6 | |
| SCHEMBL727185 | 0.73 | CYP1A2 (0.62) | CYP2A6CHRNA7HRH4HRH3CYP1A2 | |
| SCHEMBL1773262 | 0.73 | TBXAS1 (0.56) | CHRNA7MEN1KMT2AHRH4HRH3 | |
| SCHEMBL17922967 | 0.72 | MEN1 (0.45) | MEN1KMT2AMAPTHRH4HRH3 | |
| SCHEMBL14257669 | 0.72 | CYP1A2 (0.56) | CYP2A6CHRNA7HRH4HRH3CYP1A2 | |
| SCHEMBL10487080 | 0.72 | NTRK1 (0.54) | CHRNA7MEN1KMT2AMAPTPABPC1 | |
| SCHEMBL30861994 | 0.70 | PKM (0.51) | CHRNA7KMT2AHRH4HRH3CYP1A2 | |
| SCHEMBL10487072 | 0.70 | PKM (0.51) | CHRNA7KMT2AHRH4HRH3CYP1A2 | |
| SCHEMBL22172497 | 0.69 | CHRNB2 (0.50) | CHRNA7HRH4HRH3CYP1A2CYP2D6 | |
| SCHEMBL3758352 | 0.69 | TBXAS1 (0.56) | HRH4HRH3CYP1A2CYP2D6GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160102090-A1 | SUBSTITUTED 3-BENZYLQUINOXALIN-4(3H)-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYCHOLINE RECEPTOR M1 | VANDERBILT UNIVERSITY (US) | 2016-04-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160102090-A1 | SUBSTITUTED 3-BENZYLQUINOXALIN-4(3H)-ONE ANALOGS AS POSITIVE ALLOSTERIC MODULATORS OF MUSCARINIC ACETYCHOLINE RECEPTOR M1 | CHRM1, CHRM3, CHRM4 | CYP2A6 2115/4885CHRNA7 12/4885MEN1 1890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.