Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.45 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 7/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304782 | 0.97 | TBXAS1 (0.46) | CYP4F2CYP4A11TBXAS1CYP4Z1 | |
| SCHEMBL8308679 | 0.95 | CYP4F2 (0.41) | CYP4F2CYP4A11TBXAS1PDE4DALDH1A1 | |
| SCHEMBL8310036 | 0.87 | LMNA (0.43) | TBXAS1ALDH1A1LMNA | |
| SCHEMBL8304256 | 0.84 | SMN1; SMN2 (0.51) | TBXAS1ALDH1A1MEN1KMT2A | |
| SCHEMBL8308755 | 0.84 | TBXAS1 (0.67) | TBXAS1 | |
| SCHEMBL8702346 | 0.78 | TBXAS1 (0.49) | TBXAS1 | |
| SCHEMBL8304942 | 0.78 | TBXAS1 (0.54) | CYP4F2CYP4A11TBXAS1 | |
| SCHEMBL11064337 | 0.78 | CYP4F2 (0.51) | CYP4F2CYP4A11TBXAS1ALDH1A1KDM4E | |
| SCHEMBL11083416 | 0.78 | CYP4F2 (0.51) | CYP4F2CYP4A11TBXAS1ALDH1A1KDM4E | |
| SCHEMBL3957320 | 0.77 | CYP4F2 (0.55) | CYP4F2CYP4A11TBXAS1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |