Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307943 | 0.87 | CYP4F2 (0.45) | LMNATBXAS1ALDH1A1 | |
| SCHEMBL8304782 | 0.84 | TBXAS1 (0.46) | TBXAS1 | |
| SCHEMBL8308679 | 0.82 | CYP4F2 (0.41) | LMNATBXAS1ALDH1A1 | |
| SCHEMBL8310033 | 0.79 | HDAC3 (0.42) | LMNASMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL8308755 | 0.78 | TBXAS1 (0.67) | TBXAS1 | |
| SCHEMBL8304256 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2TBXAS1ALDH1A1NAMPTHTT | |
| SCHEMBL8705027 | 0.76 | EPHX1 (0.44) | LMNASMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL8305362 | 0.73 | TBXAS1 (0.76) | SMN1; SMN2HDAC2HDAC8HDAC6TBXAS1 | |
| SCHEMBL8309142 | 0.73 | TBXAS1 (0.70) | LMNATBXAS1ALDH1A1 | |
| SCHEMBL8307372 | 0.73 | TBXAS1 (0.53) | TBXAS1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |