Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8310260 | 0.88 | TBXAS1 (0.50) | CYP4F2CYP4A11NAMPTTBXAS1MAPT | |
| SCHEMBL8308660 | 0.85 | TBXAS1 (0.49) | CYP4F2CYP4A11TBXAS1 | |
| SCHEMBL8593152 | 0.85 | CYP4F2 (0.50) | CYP4F2CYP4A11CYP1A2MAPTCYP4Z1 | |
| SCHEMBL8707662 | 0.84 | CYP4F2 (0.44) | CYP4F2CYP4A11NAMPTTBXAS1MAPT | |
| SCHEMBL8707667 | 0.82 | CYP4F2 (0.42) | CYP4F2CYP4A11NAMPTTBXAS1MAPT | |
| SCHEMBL2412884 | 0.82 | CYP4F2 (0.67) | CYP4F2CYP4A11NAMPTMAPTCYP4Z1 | |
| SCHEMBL8308082 | 0.79 | CYP4F2 (0.41) | CYP4F2CYP4A11CYP1A2TBXAS1MAPT | |
| SCHEMBL8309251 | 0.79 | TBXAS1 (0.51) | TBXAS1ALDH1A1 | |
| SCHEMBL8819359 | 0.79 | CYP4F2 (0.72) | CYP4F2CYP4A11CYP1A2MAPTCYP4Z1 | |
| SCHEMBL8309155 | 0.79 | CYP17A1 (0.47) | CYP4F2CYP4A11NAMPTTBXAS1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |