Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 13/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.48 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308006 | 0.88 | CYP4F2 (0.47) | TBXAS1CYP4F2CYP4A11NAMPTCYP4Z1 | |
| SCHEMBL8707667 | 0.86 | CYP4F2 (0.42) | TBXAS1CYP4F2CYP4A11NAMPTCYP4Z1 | |
| SCHEMBL8307393 | 0.85 | TBXAS1 (0.62) | TBXAS1 | |
| SCHEMBL8707662 | 0.85 | CYP4F2 (0.44) | TBXAS1CYP4F2CYP4A11NAMPTCYP4Z1 | |
| SCHEMBL8592085 | 0.84 | CYP4F2 (0.51) | TBXAS1CYP4F2CYP4A11FFAR1CYP4Z1 | |
| SCHEMBL2412884 | 0.83 | CYP4F2 (0.67) | CYP4F2CYP4A11NAMPTCYP4Z1MAPT | |
| SCHEMBL8306769 | 0.80 | TBXAS1 (0.63) | TBXAS1 | |
| SCHEMBL8307474 | 0.80 | TBXAS1 (0.58) | TBXAS1CYP4F2CYP4A11NAMPT | |
| SCHEMBL8309155 | 0.80 | CYP17A1 (0.47) | TBXAS1CYP4F2CYP4A11NAMPTMAPT | |
| SCHEMBL8304942 | 0.79 | TBXAS1 (0.54) | TBXAS1CYP4F2CYP4A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0579618-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | Pfizer Limited (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017451-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LIMITED (GB) | 1992-10-15 | — | — | WO | disclosed |