Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308040 | 0.89 | MEN1 (0.45) | MEN1KMT2AALDH1A1MAPTGABRA1 | |
| SCHEMBL4030728 | 0.82 | KMT2A (0.44) | MEN1KMT2AALDH1A1MAPTGABRA1 | |
| SCHEMBL6284886 | 0.75 | MEN1 (0.48) | MEN1KMT2AALDH1A1GABRA1GABRG2 | |
| SCHEMBL27299549 | 0.71 | KMT2A (0.51) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL12409075 | 0.71 | NPC1 (0.50) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL6190711 | 0.71 | SYK (0.69) | SYK | |
| SCHEMBL8307415 | 0.71 | SYK (0.47) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL2977766 | 0.70 | MEN1 (0.41) | MEN1KMT2AGABRA1GABRG2GABRB3 | |
| SCHEMBL5656288 | 0.70 | KMT2A (0.37) | MEN1KMT2AALDH1A1HPGDMAPT | |
| SCHEMBL8310019 | 0.70 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPTPOLBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |