SCHEMBL8308065

SCHEMBL8308065

CSc1c(Br)cc(Cl)c2c1C(=O)CCO2

nearest known ligand 0.34

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
SIRT2 Q8IXJ6 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6725382 0.87 LMNA (0.35) LMNAMAPT
SCHEMBL8128422 0.80 FABP4 (0.34) LMNAMAPT
SCHEMBL8549154 0.78
SCHEMBL6732023 0.74 BAZ2B (0.38) LMNAMAPT
SCHEMBL8547531 0.72 LMNA (0.32) LMNAMAPT
SCHEMBL31690278 0.72 LMNA (0.39) LMNAMAPT
SCHEMBL8307110 0.72 MAOB (0.34) LMNAMAPT
SCHEMBL26504368 0.70 KDM4E (0.41)
SCHEMBL8122612 0.69 MEN1 (0.33) LMNAMAPT
SCHEMBL19682918 0.69 LMNA (0.42) LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0629623-B1 PYRAZOLE DERIVATIVE IDEMITSU KOSAN CO (JP) 1999-05-19 EP disclosed
EP-0818455-A1 PYRAZOLE DERIVATIVES IDEMITSU KOSAN COMPANY LIMITED (JP) 1998-01-14 EP disclosed
US-5587484-A HALOGENATION; OXIDATION; SULFONATION; HERBICIDES IDEMITSU KOSAN CO., LTD. (JP) 1996-12-24 US disclosed
US-5468722-A Herbicides for corn, wheat, barley IDEMITSU KOSAN CO., LTD. (JP) 1995-11-21 US disclosed
EP-0629623-A1 PYRAZOLE DERIVATIVE IDEMITSU KOSAN COMPANY LIMITED (JP) 1994-12-21 EP disclosed