SCHEMBL8308112

SCHEMBL8308112

CCOC(=O)CC(Cl)C(=O)OCC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.53
ALOX15 P16050 3/20 0.53
CYP3A4 P08684 2/20 0.53
TSHR P16473 2/20 0.53
TDP1 Q9NUW8 1/20 0.53
HSD17B10 Q99714 2/20 0.51
CHRM1 P11229 1/20 0.51
ADORA1 P30542 1/20 0.51
MGAM O43451 1/20 0.48
GAA P10253 1/20 0.48
SI P14410 1/20 0.48
MGAM2 Q2M2H8 1/20 0.48
TRPA1 O75762 1/20 0.44
KDM4E B2RXH2 2/20 0.39
CYP2D6 P10635 1/20 0.39
HTT P42858 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CYP1A2 P05177 1/20 0.39
LMNA P02545 2/20 0.39
SOAT1 P35610 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6809972 1.00 ALDH1A1 (0.53) ALDH1A1ALOX15CYP3A4TSHRTDP1
SCHEMBL6806491 1.00 ALDH1A1 (0.53) ALDH1A1ALOX15CYP3A4TSHRTDP1
SCHEMBL4808766 0.84 GAA (0.46) ALDH1A1ALOX15CYP3A4TSHRTDP1
SCHEMBL8155495 0.82 ALDH1A1 (0.42) ALDH1A1ALOX15CYP3A4TSHRTDP1
SCHEMBL28160177 0.82 ALDH1A1 (0.44) ALDH1A1ALOX15CYP3A4TSHRTDP1
SCHEMBL8307598 0.82 ALDH1A1 (0.41) ALDH1A1ALOX15CYP3A4TSHRTDP1
SCHEMBL8677 0.81
SCHEMBL9461850 0.81 GAA (0.54) ALDH1A1ALOX15CYP3A4TSHRTDP1
SCHEMBL3817055 0.81 MGAM (0.43) ALDH1A1ALOX15CYP3A4TSHRTDP1
SCHEMBL4811640 0.81 MGAM (0.43) ALDH1A1ALOX15CYP3A4TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109400578-A A kind of imazamox production technology 宁夏海天精细化工有限公司 2019-03-01 CN claimed
CN-109400578-A A kind of imazamox production technology 宁夏海天精细化工有限公司 2019-03-01 CN disclosed
EP-0758312-B1 SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS LILLY CO ELI (US) 1999-12-22 EP disclosed
EP-0758312-A4 SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS LILLY CO ELI (US) 1997-09-10 EP disclosed
EP-0758312-A1 SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS ELI LILLY AND COMPANY (US) 1997-02-19 EP disclosed
US-5583221-A ANTIINFLAMMATORY AGENTS, CARDIOVASCULAR DISORDERS, VIRICIDES, FUNGICIDES ELI LILLY AND COMPANY (US) 1996-12-10 US disclosed
WO-1996005729-A1 VICINAL-SUBSTITUTED CARBOCYCLIC COMPOUNDS AS THERAPEUTIC AGENTS ELI LILLY AND COMPANY (US) 1996-02-29 WO disclosed
EP-0687249-A1 BALANOIDS ELI LILLY AND COMPANY (US) 1995-12-20 EP disclosed
WO-1995030640-A1 SUBSTITUTED FUSED AND BRIDGED BICYCLIC COMPOUNDS AS THERAPEUTIC AGENTS ELI LILLY AND COMPANY (US) 1995-11-16 WO disclosed
US-5432198-A Enzyme inhibitors SPHINX PHARMACEUTICALS CORPORATION (US) 1995-07-11 US disclosed
WO-1994020062-A2 BALANOIDS AS PROTEIN KINASE C INHIBITORS ELI LILLY AND COMPANY (US) 1994-09-15 WO disclosed
US-5075488-A Fungicides SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-12-24 US disclosed
EP-0128006-B1 A SOIL-DISEASE-CONTROLLING AGENT SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1991-09-18 EP disclosed
US-4709052-A FUNGICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1987-11-24 US disclosed
EP-0128006-A2 A soil-disease-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-12 EP disclosed
US-4356295-A COORDINATION CATALYSTS MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) 1982-10-26 US disclosed
US-4216099-A Bridged phenol metal salt/halo carboxylic acid condensate additives for lubricants THE LUBRIZOL CORPORATION (US) 1980-08-05 US disclosed
US-4131554-A Overbased bridged phenol metal salt/halo carboxylic acid condensate additives for lubricants THE LUBRIZOL CORPORATION (US) 1978-12-26 US disclosed
US-4067698-A Bridged phenol metal salt-halo carboxylic acid condensate additives for fuels THE LUBRIZOL CORPORATION (US) 1978-01-10 US disclosed