Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30354833 | 0.81 | MAPT (0.54) | GAACYP1A2CYP2D6MAPTCYP2C19 | |
| SCHEMBL8309407 | 0.76 | HPGD (0.54) | CYP1A2CYP2D6CYP3A4NPC1MAPT | |
| SCHEMBL2986980 | 0.75 | EGFR (0.44) | MRGPRX4CYP3A4NPC1MAPTCYP2C19 | |
| SCHEMBL632895 | 0.74 | MRGPRX4 (0.57) | MRGPRX4GAAL3MBTL1NPC1MAPT | |
| SCHEMBL7890449 | 0.74 | MAOB (0.52) | TDP1GAACYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL23537705 | 0.74 | L3MBTL1 (0.51) | TDP1MRGPRX4CYP1A2L3MBTL1CYP3A4 | |
| SCHEMBL6210923 | 0.74 | CCR5 (0.48) | TDP1MRGPRX4GAACYP1A2CYP2D6 | |
| SCHEMBL1893529 | 0.73 | CYP3A4 (0.39) | TDP1GAACYP1A2CYP2D6L3MBTL1 | |
| SCHEMBL14855083 | 0.73 | IDO1 (0.50) | TDP1MRGPRX4NPC1MAPTHTT | |
| SCHEMBL4028096 | 0.73 | SYK (0.54) | TDP1MRGPRX4GAAL3MBTL1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |