Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 6/20 | 0.58 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.53 |
| ▸ | ITGAL | P20701 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29199082 | 0.83 | PDE7A (0.61) | PDE7AITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL6264703 | 0.83 | PDE7A (0.43) | PDE7AITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL7187676 | 0.78 | ITGB2 (0.80) | PDE7AITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL9724130 | 0.77 | PDE7A (0.54) | PDE7AALDH1A1NPSR1TSHRFBP1 | |
| SCHEMBL8309413 | 0.74 | PDE7A (1.00) | PDE7AALDH1A1MAPTKMT2AHSD17B10 | |
| SCHEMBL5253210 | 0.72 | PDE7A (0.79) | PDE7AITGB2ICAM1ITGALALDH1A1 | |
| Hydrochloric Acid SCHEMBL7615653 | 0.72 | ITGB2 (0.70) | PDE7AITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL4034133 | 0.71 | FBP1 (0.54) | PDE7AITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL7187848 | 0.71 | PDE7A (1.00) | PDE7AITGB2ICAM1ITGALALDH1A1 | |
| SCHEMBL7610324 | 0.71 | ITGB2 (0.96) | PDE7AITGB2ICAM1ITGALALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |