Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 3/20 | 0.43 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.33 |
| ▸ | ITGAL | P20701 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308899 | 0.83 | PDE7A (0.58) | PDE7AFBP1PTGS2KDM4EMAPT | |
| SCHEMBL9346269 | 0.76 | ITGB2 (0.48) | PDE7AKDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL30565314 | 0.76 | ITGB2 (0.48) | PDE7AKDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL28656445 | 0.73 | FBP1 (0.43) | PDE7AFBP1KCNH2PTGS2KDM4E | |
| SCHEMBL2432241 | 0.71 | FBP1 (0.68) | PDE7AFBP1PTGS2KDM4EMAPT | |
| SCHEMBL9631752 | 0.69 | ALDH1A1 (0.61) | PDE7AKDM4EMAPTHPGDALDH1A1 | |
| SCHEMBL11729689 | 0.69 | KCNH2 (0.46) | PDE7AFBP1KCNH2ALDH1A1NPC1 | |
| SCHEMBL9539495 | 0.69 | PDE7A (0.39) | PDE7AFBP1KCNH2PTGS2KDM4E | |
| SCHEMBL29199082 | 0.68 | PDE7A (0.61) | PDE7AFBP1KDM4EMAPTALDH1A1 | |
| SCHEMBL9573601 | 0.67 | ALDH1A1 (0.50) | PDE7AKDM4EMAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005053609-A2 | METHODS OF NAD+-DEPENDENT DEACETYLASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005053609-A2 | METHODS OF NAD+-DEPENDENT DEACETYLASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 2005-06-16 | — | — | WO | disclosed |