Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.44 |
| ▸ | RAF1 | P04049 | 5/20 | 0.43 |
| ▸ | BRAF | P15056 | 5/20 | 0.43 |
| ▸ | RET | P07949 | 2/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | KIF5B | P33176 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308341 | 0.89 | IGF1R (0.50) | EGFRALKRIPK2RAF1BRAF | |
| SCHEMBL8449810 | 0.85 | EGFR (0.49) | EGFRRIPK2ERBB2GCK | |
| Hydrochloric Acid SCHEMBL8305108 | 0.84 | EGFR (0.48) | EGFRRIPK2ERBB2GCK | |
| SCHEMBL8307394 | 0.83 | EGFR (0.45) | EGFRRIPK2ERBB2GCK | |
| SCHEMBL8307493 | 0.82 | EGFR (0.46) | EGFRRIPK2ERBB2GCK | |
| SCHEMBL8615598 | 0.79 | GCK (0.40) | BRAFGCK | |
| SCHEMBL5567997 | 0.77 | EGFR (0.48) | EGFRERBB2GCK | |
| SCHEMBL7763004 | 0.76 | ALK (0.60) | EGFRALKRIPK2RAF1BRAF | |
| SCHEMBL8812643 | 0.76 | ALK (0.43) | EGFRALKRIPK2RAF1BRAF | |
| SCHEMBL5567991 | 0.74 | EGFR (0.56) | EGFRERBB2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |
| EP-0790986-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015118-A1 | ANILINE DERIVATIVES | ZENECA LIMITED (GB) | 1996-05-23 | — | — | WO | disclosed |