Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8615048 | 0.89 | IGF1R (0.50) | IGF1RMAP2K1 | |
| SCHEMBL8615673 | 0.82 | BRAF (0.41) | GCKBRAFIGF1RMAP2K1 | |
| SCHEMBL8308906 | 0.79 | EGFR (0.46) | GCKBRAF | |
| SCHEMBL8618439 | 0.72 | IGF1R (0.62) | IGF1RMAP2K1 | |
| Hydrochloric Acid SCHEMBL8620309 | 0.72 | IGF1R (0.61) | IGF1RMAP2K1 | |
| SCHEMBL13363011 | 0.68 | BRAF (0.55) | BRAF | |
| SCHEMBL8308341 | 0.67 | IGF1R (0.50) | BRAFIGF1RMAP2K1 | |
| SCHEMBL8449810 | 0.67 | EGFR (0.49) | GCK | |
| SCHEMBL4029532 | 0.67 | GCK (0.54) | GCK | |
| SCHEMBL3429200 | 0.67 | BRAF (0.52) | BRAFSYKAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821246-A | USEFUL AS TYROSINE KINASE INHIBITORS AND FOR THE TREATMENT OF PROLIFERATIVE DISEASES SUCH AS CANCER | ZENECA LIMITED (GB) | 1998-10-13 | — | — | US | disclosed |