Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.65 |
| ▸ | ACHE | P22303 | 3/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11619160 | 0.86 | HTR1A (0.67) | HTR1AACHESLC6A4HTR2AADRA2A | |
| SCHEMBL8306860 | 0.82 | HTR1A (0.62) | HTR1AACHESLC6A4SLC6A2SLC6A3 | |
| SCHEMBL11223454 | 0.81 | DRD2 (0.67) | HTR1AACHESLC6A4HTR2ASLC6A3 | |
| Hydrochloric Acid SCHEMBL11616673 | 0.80 | DRD2 (0.66) | HTR1AACHESLC6A4HTR2ASLC6A3 | |
| SCHEMBL8314934 | 0.79 | HTR2A (0.52) | HTR1ASLC6A4HTR2ASLC6A3ADRA2B | |
| SCHEMBL11617634 | 0.78 | HTR2A (0.49) | HTR2A | |
| SCHEMBL9114665 | 0.77 | DRD2 (0.49) | HTR2A | |
| SCHEMBL8557415 | 0.77 | HTR1A (0.64) | HTR1ASLC6A4HTR2AADRA2AADRA2B | |
| SCHEMBL8555729 | 0.77 | HTR1A (0.64) | HTR1ASLC6A4HTR2AADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL11614743 | 0.77 | HTR2A (0.49) | HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747379-B1 | Derivatives of indole, indazole and benzisoxazole for the treatment of schizophrenia | ADIR (FR) | 1999-08-11 | — | — | EP | disclosed |
| EP-0747379-A1 | Derivatives of indole, indazole and benzisoxazole for the treatment of schizophrenia | ADIR ET COMPAGNIE (FR) | 1996-12-11 | — | — | EP | disclosed |