Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 0.52 |
| ▸ | HTR2C | P28335 | 6/20 | 0.52 |
| ▸ | HTR7 | P34969 | 4/20 | 0.52 |
| ▸ | HTR6 | P50406 | 4/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318974 | 0.82 | HTR2A (0.53) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL9117585 | 0.80 | HTR2A (0.51) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL8309219 | 0.79 | HTR1A (0.65) | HTR2AHTR1AADRA2BADRA2CSLC6A4 | |
| SCHEMBL11617634 | 0.77 | HTR2A (0.49) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL11009545 | 0.77 | HTR2A (0.72) | HTR2AHTR2CHTR7HTR6DRD2 | |
| Hydrochloric Acid SCHEMBL11614743 | 0.76 | HTR2A (0.49) | HTR2AHTR2CHTR7HTR6DRD2 | |
| Hydrochloric Acid SCHEMBL8916858 | 0.75 | HSD11B1 (0.49) | HTR2AHTR2CDRD2ALDH1A1LMNA | |
| SCHEMBL9114665 | 0.75 | DRD2 (0.49) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL9115981 | 0.74 | HTR2A (0.50) | HTR2AHTR2CHTR7HTR6DRD2 | |
| SCHEMBL9115963 | 0.74 | HTR2A (0.50) | HTR2AHTR2CHTR7HTR6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | claimed |
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |