Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | TBXAS1 | P24557 | 15/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8304256 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2TBXAS1NAMPTTSHR | |
| SCHEMBL9183046 | 0.78 | TBXAS1 (0.80) | TBXAS1TBXA2R | |
| SCHEMBL8309876 | 0.77 | TBXAS1 (0.86) | TBXAS1TBXA2R | |
| SCHEMBL8308771 | 0.76 | TBXAS1 (0.71) | SMN1; SMN2TBXAS1NPSR1NAMPTTSHR | |
| SCHEMBL11113512 | 0.74 | NPSR1 (0.68) | SMN1; SMN2NPSR1TSHR | |
| SCHEMBL8304782 | 0.74 | TBXAS1 (0.46) | TBXAS1 | |
| SCHEMBL8307943 | 0.70 | CYP4F2 (0.45) | TBXAS1 | |
| SCHEMBL8309678 | 0.70 | TBXAS1 (1.00) | TBXAS1TBXA2R | |
| SCHEMBL8308755 | 0.70 | TBXAS1 (0.67) | TBXAS1TBXA2R | |
| SCHEMBL9312115 | 0.69 | TBXAS1 (0.61) | SMN1; SMN2TBXAS1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |