Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 19/20 | 0.86 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309678 | 0.93 | TBXAS1 (1.00) | TBXAS1TBXA2R | |
| SCHEMBL8309142 | 0.89 | TBXAS1 (0.70) | TBXAS1TBXA2RALDH1A1 | |
| SCHEMBL8309213 | 0.83 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL8309896 | 0.81 | TBXAS1 (0.80) | TBXAS1TBXA2R | |
| SCHEMBL9183046 | 0.81 | TBXAS1 (0.80) | TBXAS1TBXA2R | |
| SCHEMBL8309534 | 0.80 | TBXAS1 (1.00) | TBXAS1TBXA2RALDH1A1MAPT | |
| SCHEMBL9177531 | 0.79 | TBXAS1 (0.86) | TBXAS1TBXA2RALDH1A1MAPT | |
| SCHEMBL8309357 | 0.78 | TBXAS1 (0.58) | TBXAS1TBXA2RALDH1A1MAPT | |
| SCHEMBL8310769 | 0.77 | TBXAS1 (1.00) | TBXAS1 | |
| SCHEMBL8309360 | 0.77 | SMN1; SMN2 (0.55) | TBXAS1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |