Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 15/20 | 0.52 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8308559 | 0.88 | TBXAS1 (0.58) | TBXAS1 | |
| SCHEMBL8703687 | 0.83 | TBXAS1 (0.57) | TBXAS1ALDH1A1LMNAF2F10 | |
| SCHEMBL8308276 | 0.83 | TBXAS1 (0.49) | TBXAS1 | |
| SCHEMBL8309224 | 0.82 | CYP3A4 (0.48) | TBXAS1 | |
| SCHEMBL8701528 | 0.82 | TBXAS1 (0.49) | TBXAS1ALDH1A1LMNANLRP3 | |
| SCHEMBL16508902 | 0.82 | TBXAS1 (0.57) | TBXAS1ALDH1A1LMNANLRP3 | |
| SCHEMBL8306676 | 0.79 | TBXAS1 (0.70) | TBXAS1 | |
| SCHEMBL8308660 | 0.77 | TBXAS1 (0.49) | TBXAS1CHRNA7 | |
| SCHEMBL11059401 | 0.72 | TBXAS1 (0.71) | TBXAS1ALDH1A1LMNA | |
| SCHEMBL8309308 | 0.72 | TBXAS1 (0.60) | TBXAS1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |
| EP-0579618-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | Pfizer Limited (GB) | 1994-01-26 | — | — | EP | disclosed |
| WO-1992017451-A1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LIMITED (GB) | 1992-10-15 | — | — | WO | disclosed |