Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247061 | 0.86 | SLC1A3 (0.44) | SLC1A3SLC1A2SLC1A1NPC1CA12 | |
| SCHEMBL4675889 | 0.81 | — | — | |
| SCHEMBL27892463 | 0.81 | — | — | |
| SCHEMBL29794511 | 0.80 | SLC1A3 (0.43) | SLC1A3SLC1A2SLC1A1LMNAZDHHC20 | |
| SCHEMBL3441145 | 0.79 | — | — | |
| SCHEMBL10011426 | 0.76 | NPC1 (0.42) | SLC1A3SLC1A2SLC1A1NPC1CA12 | |
| SCHEMBL4676330 | 0.76 | — | — | |
| SCHEMBL2764994 | 0.74 | ALOX15 (0.44) | NPC1CYP2D6LMNA | |
| SCHEMBL1338583 | 0.74 | ALOX15 (0.44) | NPC1CYP2D6LMNA | |
| SCHEMBL1671835 | 0.74 | ALOX15 (0.44) | NPC1CYP2D6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE46129-E1 | Dimeric small molecule potentiators of apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-08-30 | — | — | US | disclosed |
| EP-1723122-B1 | Dimeric small molecule potentiators of apoptosis | UNIV TEXAS (US) | 2014-11-19 | — | — | EP | disclosed |
| US-8143418-B2 | Dimeric small molecule potentiators of apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110124585-A1 | Dimeric Small Molecule Potentiators of Apoptosis | BOARD OF REGENTS | 2011-05-26 | — | — | US | disclosed |
| US-7884211-B2 | 2-Methylamino-N-{2-(6-{1-methyl-2-(2-methylamino-propionylamino)-3-oxo-3-[2-(5-phenoxy-tetrazol-1-ylmethyl)-pyrrolidine-1-yl]-propoxy}-hexa-2,4-diynyloxy)-1-[2-(5-phenoxy-tetrazol-1-ylmethyl)-pyrrolidine-1-carbonyl]-propyl}-propionamide; mimetics of second mitochondria-derived activator of caspases | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-02-08 | — | — | US | disclosed |
| US-7816538-B2 | Dimeric small molecule potentiators of apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2010-10-19 | — | — | US | disclosed |
| US-7638544-B2 | Dimeric small molecule potentiators of apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-12-29 | — | — | US | disclosed |
| US-20090312379-A1 | Dimeric Small Molecule Potentiators of Apoptosis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-12-17 | — | — | US | disclosed |
| US-20090281155-A1 | Dimeric Small Molecule Potentiators of Apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2009-11-12 | — | — | US | disclosed |
| US-20080119532-A1 | Dimeric Small Molecule Potentiators of Apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2008-05-22 | — | — | US | disclosed |
| US-7309792-B2 | Dimeric small molecule potentiators of apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2007-12-18 | — | — | US | disclosed |
| EP-1723122-A2 | DIMERIC SMALL MOLECULE POTENTIATORS OF APOPTOSIS | Board of Regents, The University of Texas System (US) | 2006-11-22 | — | — | EP | disclosed |
| WO-2005084317-A2 | DIMERIC SMALL MOLECULE POTENTIATORS OF APOPTOSIS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2005-09-15 | — | — | WO | disclosed |
| US-20050197403-A1 | Dimeric small molecule potentiators of apoptosis | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312379-A1 | Dimeric Small Molecule Potentiators of Apoptosis | BAD, BAX, CASP2 | SLC1A3 4823/4885SLC1A2 4708/4885SLC1A1 4828/4885 |
| US-20090281155-A1 | Dimeric Small Molecule Potentiators of Apoptosis | BAD, BAX, CASP2 | SLC1A3 4823/4885SLC1A2 4708/4885SLC1A1 4828/4885 |
| US-20110124585-A1 | Dimeric Small Molecule Potentiators of Apoptosis | BAD, BAX, CASP2 | SLC1A3 4823/4885SLC1A2 4708/4885SLC1A1 4828/4885 |
| US-20080119532-A1 | Dimeric Small Molecule Potentiators of Apoptosis | BAD, BAX, CASP2 | SLC1A3 4828/4885SLC1A2 4734/4885SLC1A1 4830/4885 |
| US-20050197403-A1 | Dimeric small molecule potentiators of apoptosis | BAD, BAX, CASP2 | SLC1A3 4843/4885SLC1A2 4779/4885SLC1A1 4848/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.