Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | STAT1 | P42224 | 1/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309863 | 0.90 | GAA (0.60) | MAPTLMNAALDH1A1HPGDGAA | |
| SCHEMBL18988497 | 0.86 | MAPT (0.55) | MAPTLMNAALDH1A1HPGDGAA | |
| SCHEMBL18988429 | 0.86 | ADORA1 (0.56) | MAPTLMNAALDH1A1HPGDGAA | |
| SCHEMBL8308061 | 0.85 | GAA (0.53) | MAPTLMNAALDH1A1HPGDGAA | |
| SCHEMBL14833516 | 0.84 | BRAF (0.58) | MAPTLMNAALDH1A1HPGDGAA | |
| SCHEMBL8915986 | 0.82 | L3MBTL1 (0.54) | MAPTLMNAALDH1A1HPGDGAA | |
| SCHEMBL2546236 | 0.81 | GAA (0.68) | MAPTLMNAALDH1A1HPGDGAA | |
| SCHEMBL8915716 | 0.80 | ADORA1 (0.59) | MAPTALDH1A1HPGDGAAADORA1 | |
| SCHEMBL18988488 | 0.80 | MAPT (0.59) | MAPTLMNAALDH1A1HPGDGAA | |
| SCHEMBL29544710 | 0.80 | MAPT (0.59) | MAPTLMNAALDH1A1HPGDGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5922741-A | 5-aminopyrazoles useful as tyrosine kinase inhibitors | CELLTECH THERAPEUTICS LTD. (GB) | 1999-07-13 | — | — | US | disclosed |
| EP-0906286-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997040019-A1 | 5-AMINOPYRAZOLES USEFUL AS SELECTIVE INHIBITORS OF THE PROTEIN TYROSINE KINASE P56ICK | CELLTECH THERAPEUTICS LIMITED (GB) | 1997-10-30 | — | — | WO | disclosed |
| US-5593997-A | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors | PFIZER INC. (US) | 1997-01-14 | — | — | US | disclosed |