Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 7/20 | 0.59 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.59 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.51 |
| ▸ | CDK2 | P24941 | 4/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 2/20 | 0.50 |
| ▸ | CDK4 | P11802 | 2/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.50 |
| ▸ | CCND1 | P24385 | 2/20 | 0.50 |
| ▸ | CDK7 | P50613 | 2/20 | 0.50 |
| ▸ | CCNH | P51946 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309863 | 0.86 | GAA (0.60) | ADORA1ADORA2ANPC1RAB9AHPGD | |
| SCHEMBL1682478 | 0.81 | LMNA (0.55) | ADORA1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL8309622 | 0.80 | MAPT (0.57) | ADORA1ADORA2ANPC1RAB9AHPGD | |
| SCHEMBL14833516 | 0.79 | BRAF (0.58) | ADORA1ADORA2ANPC1RAB9AHPGD | |
| SCHEMBL8917674 | 0.78 | ALDH1A1 (0.58) | ADORA1ADORA2ANPC1RAB9AHPGD | |
| SCHEMBL18988429 | 0.77 | ADORA1 (0.56) | ADORA1ADORA2ANPC1RAB9AHPGD | |
| SCHEMBL8918890 | 0.77 | HTT (0.53) | ADORA1ADORA2AHPGDSMN1; SMN2ADORA2B | |
| SCHEMBL8308061 | 0.77 | GAA (0.53) | ADORA1ADORA2ANPC1RAB9AHPGD | |
| SCHEMBL11899876 | 0.76 | GAA (0.71) | ADORA1NPC1RAB9AHPGDSMN1; SMN2 | |
| SCHEMBL14132511 | 0.76 | RAB9A (0.63) | ADORA2ANPC1RAB9AHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5593997-A | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors | PFIZER INC. (US) | 1997-01-14 | — | — | US | disclosed |