Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 8/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14833516 | 0.91 | BRAF (0.58) | GAAADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL18988429 | 0.90 | ADORA1 (0.56) | GAAADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL8309622 | 0.90 | MAPT (0.57) | GAAADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL8308061 | 0.86 | GAA (0.53) | GAAADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL8915716 | 0.86 | ADORA1 (0.59) | GAAADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL8917674 | 0.84 | ALDH1A1 (0.58) | GAAADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL8918890 | 0.83 | HTT (0.53) | GAAADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL11546523 | 0.81 | GAA (0.65) | GAAALDH1A1KDM4EHPGDLMNA | |
| SCHEMBL8914681 | 0.81 | PLAUR (0.51) | GAAADORA1ADORA2AALDH1A1KDM4E | |
| SCHEMBL8915404 | 0.81 | ALDH1A1 (0.49) | GAAADORA1ADORA2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0745684-B1 | Method of quantitative determination of peroxides, a peroxidation-active substance or a pyrazolopyridopyridazine derivative | KYOWA MEDEX CO LTD (JP) | 1999-08-11 | — | — | EP | disclosed |
| US-5801008-A | Method of quantitative determination of peroxide, a peroxidation-active substance or a pyrazolopyridopyridazine derivative | KYOWA MEDEX CO., LTD. (JP) | 1998-09-01 | — | — | US | disclosed |
| US-5593997-A | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors | PFIZER INC. (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0745684-A1 | Method of quantitative determination of peroxide, a peroxidation-active substance or a pyrazolopyridopyridazine derivative | KYOWA MEDEX CO., LTD. (JP) | 1996-12-04 | — | — | EP | disclosed |