Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | EGFR | P00533 | 7/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.46 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | CRHBP | P24387 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306485 | 0.85 | EGFR (0.53) | MAPTEGFRMEN1KMT2AERBB2 | |
| SCHEMBL8305114 | 0.84 | EGFR (0.49) | MAPTEGFRMEN1KMT2AERBB2 | |
| SCHEMBL8309481 | 0.82 | EGFR (0.50) | MAPTEGFRMEN1KMT2AERBB2 | |
| SCHEMBL8309434 | 0.81 | EGFR (0.66) | EGFRERBB2ERBB4CCNT1GSK3B | |
| SCHEMBL8306919 | 0.81 | KDR (0.65) | EGFRERBB2ERBB4 | |
| SCHEMBL8620298 | 0.80 | LMNA (0.41) | ALDH1A1MAPTMEN1KMT2APOLB | |
| SCHEMBL3244620 | 0.79 | EGFR (0.70) | ALDH1A1MAPTHTTEGFRL3MBTL1 | |
| SCHEMBL8782984 | 0.79 | DYRK1A (0.53) | MAPTEGFRMEN1KMT2AERBB2 | |
| SCHEMBL8308072 | 0.79 | EGFR (0.49) | ALDH1A1EGFRERBB2ERBB4CCNT1 | |
| SCHEMBL8443996 | 0.78 | CYP3A4 (0.54) | MAPTEGFRMEN1KMT2AERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790986-B1 | ANILINE DERIVATIVES | ZENECA LTD (GB) | 1999-01-20 | — | — | EP | disclosed |