Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 18/20 | 0.70 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8309896 | 0.92 | TBXAS1 (0.80) | TBXAS1TBXA2R | |
| SCHEMBL8309876 | 0.89 | TBXAS1 (0.86) | TBXAS1TBXA2RALDH1A1 | |
| SCHEMBL8308578 | 0.85 | TBXAS1 (0.77) | TBXAS1TSHR | |
| SCHEMBL8308755 | 0.84 | TBXAS1 (0.67) | TBXAS1TBXA2R | |
| SCHEMBL8309271 | 0.84 | TBXAS1 (0.79) | TBXAS1TBXA2RTSHRALDH1A1LMNA | |
| SCHEMBL8309013 | 0.82 | TBXAS1 (0.68) | TBXAS1TBXA2R | |
| SCHEMBL8309678 | 0.82 | TBXAS1 (1.00) | TBXAS1TBXA2R | |
| SCHEMBL8304255 | 0.81 | TBXAS1 (0.47) | TBXAS1TBXA2RALDH1A1LMNA | |
| SCHEMBL8306769 | 0.81 | TBXAS1 (0.63) | TBXAS1TSHRALDH1A1LMNA | |
| SCHEMBL8304256 | 0.79 | SMN1; SMN2 (0.51) | TBXAS1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0579618-B1 | PYRIDINE- AND IMIDAZOLE-DERIVED AGENTS FOR CARDIOVASCULAR DISEASES | PFIZER LTD (GB) | 1999-10-13 | — | — | EP | disclosed |
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5705523-A | THROMBOXANE A2 SYNTHETASE INHIBITORS | PFIZER INC. (US) | 1998-01-06 | — | — | US | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |
| US-5457118-A | Pyridine derived agents for cardiovascular diseases | PFIZER INC. (US) | 1995-10-10 | — | — | US | disclosed |