Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 3/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.53 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.52 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.52 |
| ▸ | P4HA1 | P13674 | 1/20 | 0.49 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.47 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5129590 | 0.83 | LDHA (0.59) | LDHAP4HA1P4HTMABL1DHODH | |
| SCHEMBL2251685 | 0.82 | LDHA (0.62) | LDHADYRK1AP4HA1P4HTMHPGDS | |
| SCHEMBL5515377 | 0.82 | KMO (0.56) | CSNK2A2CSNK2BDHODHMRGPRX4 | |
| SCHEMBL503140 | 0.81 | LDHA (0.79) | LDHAP4HA1P4HTMHPGDSCYP4F2 | |
| SCHEMBL29784241 | 0.80 | RXRA (0.61) | CSNK2A2CSNK2BSLC6A7DHODH | |
| SCHEMBL505417 | 0.80 | RXRA (0.61) | CSNK2A2CSNK2BSLC6A7DHODH | |
| SCHEMBL1111583 | 0.80 | RXRA (0.68) | LDHAP4HA1P4HTMHPGDSFYN | |
| SCHEMBL31243316 | 0.80 | LDHA (0.77) | LDHAP4HA1P4HTMHPGDSCYP4F2 | |
| SCHEMBL5934534 | 0.80 | TRPV1 (0.60) | ABL1 | |
| SCHEMBL3409448 | 0.79 | DYRK1A (0.50) | DYRK1AFYNXDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5872136-A | Arylheteroaryl inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| EP-0891361-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036901-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |