Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.60 |
| ▸ | ACHE | P22303 | 4/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | MPO | P05164 | 3/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8306860 | 0.90 | HTR1A (0.62) | HTR1AACHEDRD2SLC6A4 | |
| SCHEMBL8306212 | 0.85 | HTR2A (0.55) | HTR1AACHEDRD2SLC6A4HTR2A | |
| Hydrochloric Acid SCHEMBL9073679 | 0.84 | HTR2A (0.54) | HTR1AACHEDRD2SLC6A4HTR2A | |
| SCHEMBL14359185 | 0.83 | HTR1A (0.69) | HTR1AMPOSLC6A4HTR2AHTR7 | |
| SCHEMBL14358873 | 0.79 | HTR1A (0.72) | HTR1AMPOSLC6A4HTR7KCNH2 | |
| SCHEMBL7379763 | 0.77 | MEN1 (0.70) | HTR1ADRD2HTR2AKCNH2 | |
| SCHEMBL14358506 | 0.77 | HTR1A (0.59) | HTR1ADRD2MPOSLC6A4HTR2A | |
| SCHEMBL14359104 | 0.76 | HTR1A (0.71) | HTR1AMPOSLC6A4HTR2A | |
| SCHEMBL30504837 | 0.76 | HTR1A (0.84) | HTR1AACHEMPOSLC6A4 | |
| SCHEMBL6953004 | 0.75 | MPO (0.63) | HTR1AMPOSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747379-B1 | Derivatives of indole, indazole and benzisoxazole for the treatment of schizophrenia | ADIR (FR) | 1999-08-11 | — | — | EP | disclosed |
| EP-0747379-A1 | Derivatives of indole, indazole and benzisoxazole for the treatment of schizophrenia | ADIR ET COMPAGNIE (FR) | 1996-12-11 | — | — | EP | disclosed |