Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 17/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 11/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315887 | 0.90 | SLC6A3 (0.38) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL8315731 | 0.84 | SLC6A3 (0.40) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL8311382 | 0.83 | SLC6A2 (0.41) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL8564503 | 0.79 | SLC6A3 (0.37) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL8882804 | 0.78 | SLC6A3 (0.36) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL9027072 | 0.78 | SLC6A3 (0.35) | SLC6A3SLC6A4SLC6A2KCNH2CYP2D6 | |
| SCHEMBL6950573 | 0.75 | TACR1 (0.39) | SLC6A3SLC6A4SLC6A2CYP2D6 | |
| SCHEMBL7764201 | 0.74 | TACR1 (0.40) | SLC6A3SLC6A4SLC6A2CYP2D6 | |
| SCHEMBL8204373 | 0.73 | SLC6A3 (0.39) | SLC6A3SLC6A4SLC6A2CYP3A4 | |
| SCHEMBL7766689 | 0.72 | SLC6A3 (0.39) | SLC6A3SLC6A4SLC6A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0591040-B1 | Quaternary basic amides as tachykinines antagonists | SANOFI SA (FR) | 1999-02-03 | — | — | EP | disclosed |
| US-5712288-A | TACHYKININ ANTAGONIST, ANTIINFLAMMATORY, ANTIALLERGEN | SANOFI (FR) | 1998-01-27 | — | — | US | disclosed |
| US-5679693-A | TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING THE TACHYKININ SYSTEM | SANOFI (FR) | 1997-10-21 | — | — | US | disclosed |
| US-5583134-A | QUATERNARY BASIC AMIDE DERIVATIVES; USEFUL FOR TREATING PATHOLOGICAL CONDITION INVOLVING THE TACHYKININ SYSTEM | SANOFI (FR) | 1996-12-10 | — | — | US | disclosed |
| US-5554763-A | TACHYKININ ANTAGONISTS | SANOFI (FR) | 1996-09-10 | — | — | US | disclosed |
| EP-0591040-A1 | Quaternary basic amides as tachykinines antagonists | SANOFI (FR) | 1994-04-06 | — | — | EP | disclosed |