Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 18/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 15/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027072 | 0.95 | SLC6A3 (0.35) | SLC6A3SLC6A4SLC6A2OPRM1OPRL1 | |
| SCHEMBL8310465 | 0.78 | SLC6A3 (0.37) | SLC6A3SLC6A4SLC6A2CYP1A1CYP1A2 | |
| SCHEMBL8315887 | 0.78 | SLC6A3 (0.38) | SLC6A3SLC6A4SLC6A2CYP1A1CYP1A2 | |
| SCHEMBL8315731 | 0.78 | SLC6A3 (0.40) | SLC6A3SLC6A4SLC6A2CYP1A1CYP1A2 | |
| SCHEMBL8311382 | 0.77 | SLC6A2 (0.41) | SLC6A3SLC6A4SLC6A2CYP1A1CYP1A2 | |
| SCHEMBL8882797 | 0.74 | SLC6A4 (0.39) | SLC6A3SLC6A4SLC6A2OPRM1OPRL1 | |
| SCHEMBL9027067 | 0.71 | SLC6A4 (0.38) | SLC6A3SLC6A4SLC6A2OPRM1OPRL1 | |
| SCHEMBL8702363 | 0.70 | MEN1 (0.37) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6950737 | 0.68 | TACR2 (0.45) | SLC6A3SLC6A4SLC6A2CYP1A2CYP3A4 | |
| SCHEMBL8564503 | 0.68 | SLC6A3 (0.37) | SLC6A3SLC6A4SLC6A2CYP1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5607947-A | Pyrrolidinyl tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1997-03-04 | — | — | US | disclosed |
| EP-0714891-A1 | Heterocyclic tachykinin receptor antagonists | ELI LILLY AND COMPANY (US) | 1996-06-05 | — | — | EP | disclosed |