SCHEMBL8315731

SCHEMBL8315731

CC(OC1CCCCO1)C1(c2ccc(Cl)c(Cl)c2)CCNC1

nearest known ligand 0.40

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 18/20 0.40
SLC6A2 P23975 15/20 0.40
SLC6A4 P31645 15/20 0.40
KCNH2 Q12809 6/20 0.38
CYP2D6 P10635 4/20 0.38
CYP1A2 P05177 3/20 0.38
CYP3A4 P08684 3/20 0.38
CYP1A1 P04798 2/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8311382 0.95 SLC6A2 (0.41) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
SCHEMBL8310465 0.84 SLC6A3 (0.37) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
SCHEMBL8315887 0.82 SLC6A3 (0.38) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
SCHEMBL8882804 0.78 SLC6A3 (0.36) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
SCHEMBL9027072 0.77 SLC6A3 (0.35) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
SCHEMBL8565271 0.74 SLC6A2 (0.43) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
SCHEMBL6950737 0.73 TACR2 (0.45) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
SCHEMBL6957304 0.73 SLC6A2 (0.50) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
SCHEMBL7947168 0.71 SLC6A2 (0.48) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6
Hydrochloric Acid SCHEMBL8638697 0.71 SLC6A2 (0.49) SLC6A3SLC6A2SLC6A4KCNH2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0591040-B1 Quaternary basic amides as tachykinines antagonists SANOFI SA (FR) 1999-02-03 EP disclosed
US-5712288-A TACHYKININ ANTAGONIST, ANTIINFLAMMATORY, ANTIALLERGEN SANOFI (FR) 1998-01-27 US disclosed
US-5679693-A TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING THE TACHYKININ SYSTEM SANOFI (FR) 1997-10-21 US disclosed
US-5607947-A Pyrrolidinyl tachykinin receptor antagonists ELI LILLY AND COMPANY (US) 1997-03-04 US disclosed
US-5583134-A QUATERNARY BASIC AMIDE DERIVATIVES; USEFUL FOR TREATING PATHOLOGICAL CONDITION INVOLVING THE TACHYKININ SYSTEM SANOFI (FR) 1996-12-10 US disclosed
US-5554763-A TACHYKININ ANTAGONISTS SANOFI (FR) 1996-09-10 US disclosed
EP-0714891-A1 Heterocyclic tachykinin receptor antagonists ELI LILLY AND COMPANY (US) 1996-06-05 EP disclosed
EP-0591040-A1 Quaternary basic amides as tachykinines antagonists SANOFI (FR) 1994-04-06 EP disclosed