Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | NAT1 | P18440 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8933462 | 0.88 | FABP4 (0.47) | MAPTFABP4MEN1KMT2AALDH1A1 | |
| SCHEMBL8307820 | 0.82 | DYRK1A (0.61) | MAPTNAT1MEN1KMT2AALDH1A1 | |
| SCHEMBL8933494 | 0.82 | IGF1R (0.40) | MAPTFABP4MEN1KMT2AALDH1A1 | |
| SCHEMBL8310604 | 0.79 | MAPT (0.56) | MAPTFABP4NAT1MEN1KMT2A | |
| SCHEMBL8310599 | 0.79 | MAPT (0.56) | MAPTFABP4NAT1MEN1KMT2A | |
| SCHEMBL8537294 | 0.78 | IGF1R (0.38) | MAPTFABP4MEN1KMT2AALDH1A1 | |
| SCHEMBL8933559 | 0.77 | IGF1R (0.45) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL8582708 | 0.77 | MAPT (0.76) | MAPTFABP4MEN1KMT2AALDH1A1 | |
| SCHEMBL8582710 | 0.77 | MAPT (0.76) | MAPTFABP4MEN1KMT2AALDH1A1 | |
| SCHEMBL541143 | 0.75 | MAPT (0.89) | MAPTFABP4MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | claimed |
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |