Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.36 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312406 | 1.00 | CYP1A2 (0.46) | CYP1A2LMNAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL8317131 | 0.79 | ALDH1A1 (0.46) | LMNAGLAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9281511 | 0.75 | CYP1A2 (0.50) | CYP1A2LMNAGLAALDH1A1SMN1; SMN2 | |
| SCHEMBL8311289 | 0.71 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2KMT2AKDM4ETP53 | |
| SCHEMBL9080957 | 0.70 | KMT2A (0.46) | ALDH1A1SMN1; SMN2KMT2AHPGDMAPT | |
| SCHEMBL8312072 | 0.70 | KMT2A (0.67) | LMNAGLAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL3551654 | 0.68 | ALDH1A1 (0.67) | CYP1A2GLAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL9230500 | 0.68 | EPHB3 (0.46) | ALDH1A1SMN1; SMN2KMT2AHPGDMAPT | |
| SCHEMBL28549246 | 0.66 | ALDH1A1 (0.63) | CYP1A2GLAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL7989395 | 0.66 | KMT2A (0.56) | CYP1A2ALDH1A1SMN1; SMN2KMT2AGUCY1B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649425-B1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | UPJOHN CO (US) | 1999-03-10 | — | — | EP | claimed |