SCHEMBL8311628

SCHEMBL8311628

CC(C)C(=O)OC(I)C(Cl)(Cl)Cl

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 2/20 0.33
LMNA P02545 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8310484 0.73 PRKCA (0.38) CYP2C19LMNA
SCHEMBL1264920 0.72
SCHEMBL31112537 0.69 SMN1; SMN2 (0.32)
SCHEMBL22844578 0.69 TSHR (0.32)
SCHEMBL8307759 0.68 LMNA (0.35) LMNA
SCHEMBL7300857 0.67
SCHEMBL1164230 0.67
SCHEMBL7300851 0.67
SCHEMBL8309131 0.67 LMNA (0.34) LMNA
SCHEMBL20747734 0.67 GRIN2D (0.34) CYP2C19LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5914339-A ANTI-DIABETIC AND/OR ANTIHYPERGLYCEMIA AND/OR ANTI-OBESITY AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-06-22 US disclosed
EP-0901484-A1 SUBSTITUTED 1, 3-BENZODIOXOLES AMERICAN HOME PRODUCTS CORPORATION (US) 1999-03-17 EP disclosed
WO-1997043273-A1 SUBSTITUTED 1, 3-BENZODIOXOLES AMERICAN HOME PRODUCTS CORPORATION (US) 1997-11-20 WO disclosed