Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PI4KA | P42356 | 1/20 | 0.32 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.32 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.32 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13360488 | 0.71 | POLB (0.48) | POLBMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL19006734 | 0.70 | POLB (0.52) | POLBMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL10239182 | 0.70 | POLB (0.52) | POLBMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL947830 | 0.68 | POLB (0.46) | POLBMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL28973072 | 0.68 | POLB (0.42) | SLC27A1POLBMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13360504 | 0.67 | POLB (0.44) | POLBMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL14024323 | 0.66 | MAPK1 (0.43) | SLC27A1POLBMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL13041017 | 0.66 | MAPK1 (0.64) | SLC27A1POLBMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL14278538 | 0.65 | ATM (0.46) | POLBMAPK1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL5623016 | 0.62 | DRD2 (0.48) | POLBMAPK1SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649425-B1 | PYRIDINO-, PYRROLIDINO- AND AZEPINO-SUBSTITUTED OXIMES USEFUL AS ANTI-ATHEROSCLEROSIS AND ANTI-HYPERCHOLESTEROLEMIC AGENTS | UPJOHN CO (US) | 1999-03-10 | — | — | EP | claimed |