Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.34 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.34 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13360488 | 0.75 | POLB (0.48) | POLBMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL10239182 | 0.73 | POLB (0.52) | POLBMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL19006734 | 0.73 | POLB (0.52) | POLBMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL947830 | 0.72 | POLB (0.46) | POLBMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL13360504 | 0.70 | POLB (0.44) | POLBMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL14278538 | 0.69 | ATM (0.46) | POLBMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL8311746 | 0.68 | SLC27A1 (0.39) | POLBMAPK1ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL14024323 | 0.66 | MAPK1 (0.43) | POLBMAPK1ALDH1A1SMN1; SMN2SLC27A1 | |
| SCHEMBL5623016 | 0.65 | DRD2 (0.48) | POLBMAPK1ALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL12414740 | 0.65 | ALDH1A1 (0.46) | POLBMAPK1ALDH1A1SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109476649-B | Five-membered heterocyclic compound and preparation method, pharmaceutical composition and application thereof | 苏州苏领生物医药有限公司 | 2022-07-08 | — | — | CN | disclosed |