Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.61 |
| ▸ | RAF1 | P04049 | 9/20 | 0.61 |
| ▸ | GCGR | P47871 | 9/20 | 0.60 |
| ▸ | BRAF | P15056 | 2/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7989925 | 0.85 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL30647527 | 0.84 | PIN1 (0.54) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8311915 | 0.79 | MLKL (0.44) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7992089 | 0.78 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL8311911 | 0.78 | GCGR (0.49) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL5921859 | 0.76 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6469111 | 0.76 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL7995659 | 0.76 | GCGR (0.54) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL28574062 | 0.74 | ERCC1 (0.59) | MAPK14MAPK13MAPK12MAPK11RAF1 | |
| SCHEMBL6471005 | 0.72 | MAPK13 (1.00) | MAPK14MAPK13MAPK12MAPK11RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948257-A4 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 1999-12-29 | — | — | EP | claimed |
| EP-0948257-A1 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-10-13 | — | — | EP | claimed |
| US-5955480-A | GLUCAGON RECEPTOR ANTAGONISTS, CYTOKINE INHIBITORS | MERCK & CO., INC. (US) | 1999-09-21 | — | — | US | claimed |
| WO-1998021957-A1 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | claimed |
| EP-0948257-A4 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO INC (US) | 1999-12-29 | — | — | EP | disclosed |
| EP-0948257-A1 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | Merck & Co., Inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| US-5955480-A | GLUCAGON RECEPTOR ANTAGONISTS, CYTOKINE INHIBITORS | MERCK & CO., INC. (US) | 1999-09-21 | — | — | US | disclosed |
| WO-1998021957-A1 | TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE | MERCK & CO., INC. (US) | 1998-05-28 | — | — | WO | disclosed |