Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SQOR | Q9Y6N5 | 2/20 | 0.40 |
| ▸ | USP8 | P40818 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8311135 | 0.80 | HPGD (0.43) | PDE4BMAPTALDH1A1SQORKDM4E | |
| SCHEMBL16879478 | 0.78 | ALDH1A1 (0.59) | PDE4BMAPTALDH1A1KDM4EPOLB | |
| SCHEMBL10000551 | 0.77 | TSHR (0.52) | PDE4BALDH1A1SQORLRRK2CYP11B2 | |
| SCHEMBL20240554 | 0.75 | KMT2A (0.50) | MAPTALDH1A1KDM4EPOLBGAA | |
| SCHEMBL15688500 | 0.74 | ADRA2A (0.44) | MAPTALDH1A1KDM4EKMT2ACYP11B1 | |
| SCHEMBL3287308 | 0.74 | UGCG (0.46) | PDE4BSQORSCN9A | |
| SCHEMBL17069071 | 0.74 | CLK4 (0.53) | GAAKMT2ACYP11B1CYP11B2CRHR1 | |
| SCHEMBL10000616 | 0.74 | CYP2A6 (0.42) | PDE4BALDH1A1SQORLRRK2HPGD | |
| SCHEMBL3293427 | 0.74 | ALDH1A1 (0.47) | PDE4BALDH1A1KDM4EPOLBGAA | |
| SCHEMBL12320582 | 0.73 | CRHR1 (0.50) | L3MBTL1CYP11B1CYP11B2CRHR1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628046-B1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | UNION PHARMA SCIENT APPL (FR) | 1999-05-12 | — | — | EP | disclosed |
| EP-0628045-A1 | PYRAZOLOPYRIMIDIN DERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1994-12-14 | — | — | EP | disclosed |
| EP-0628046-A1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1994-12-14 | — | — | EP | disclosed |
| WO-1993017023-A1 | PYRAZOLOPYRIMIDIN DERIVATIVES AS ANGIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1993-09-02 | — | — | WO | disclosed |
| WO-1993017024-A1 | TRIAZOLOPYRIMIDIN DERIVATIVES AS ANTIOTENSIN II RECEPTOR ANTAGONISTS | LABORATOIRES UPSA (FR) | 1993-09-02 | — | — | WO | disclosed |