Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | PARP1 | P09874 | 2/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.64 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.46 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL4726018 | 0.94 | TSHR (0.67) | TSHRHSD17B10PARP1POLBCYP3A4 | |
| Benzamide SCHEMBL572737 | 0.94 | TSHR (0.73) | TSHRHSD17B10PARP1POLBCYP3A4 | |
| Benzamide SCHEMBL694831 | 0.92 | TSHR (0.64) | TSHRHSD17B10PARP1POLBCYP3A4 | |
| Benzamide SCHEMBL7761457 | 0.83 | PARP1 (0.84) | TSHRHSD17B10PARP1POLBCYP3A4 | |
| Benzoic Acid SCHEMBL8502658 | 0.82 | TSHR (0.58) | TSHRHSD17B10OPRD1SIGMAR1ALDH1A1 | |
| Benzoic Acid SCHEMBL8503046 | 0.82 | TSHR (0.58) | TSHRHSD17B10OPRD1SIGMAR1ALDH1A1 | |
| Terephthalamide SCHEMBL27861496 | 0.81 | OPRD1 (0.47) | TSHRHSD17B10PARP1POLBCYP3A4 | |
| Terephthalamide SCHEMBL8679694 | 0.81 | OPRD1 (0.47) | TSHRHSD17B10PARP1POLBCYP3A4 | |
| Benzamide SCHEMBL4198407 | 0.81 | TSHR (0.59) | TSHRHSD17B10PARP1POLBCYP3A4 | |
| Benzamide SCHEMBL1222101 | 0.80 | PARP1 (1.00) | TSHRHSD17B10PARP1POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925286-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1999-06-30 | — | — | EP | disclosed |
| WO-1998006705-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | ZENECA LIMITED (GB) | 1998-02-19 | — | — | WO | disclosed |