Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | GFER | P55789 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6502064 | 1.00 | GPR119 (0.50) | GPR119HSD17B10SMN1; SMN2GFERNAMPT | |
| SCHEMBL6499314 | 0.80 | CHRNB2 (0.41) | SMN1; SMN2NAMPTITGB3ITGA2BRAB9A | |
| SCHEMBL5798534 | 0.79 | NOTUM (0.59) | GPR119CYP2C19 | |
| SCHEMBL8307614 | 0.78 | GPR119 (0.47) | GPR119SMN1; SMN2CYP46A1NPY5RRAB9A | |
| SCHEMBL30664035 | 0.77 | KDM4E (0.61) | GPR119SMN1; SMN2NPY5RRAB9AALDH1A1 | |
| SCHEMBL31401347 | 0.77 | KDM4E (0.61) | GPR119SMN1; SMN2NPY5RRAB9AALDH1A1 | |
| SCHEMBL6500777 | 0.76 | CTSA (0.41) | SMN1; SMN2NAMPTCYP46A1RAB9AHPGD | |
| SCHEMBL4392645 | 0.75 | GPR119 (0.53) | GPR119ALDH1A1 | |
| SCHEMBL31516268 | 0.75 | NOTUM (0.71) | — | |
| SCHEMBL30663949 | 0.75 | GPR119 (0.53) | GPR119ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |