Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.45 |
| ▸ | CYP46A1 | Q9Y6A2 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5798534 | 0.78 | NOTUM (0.59) | GPR119NOTUMCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL8312595 | 0.78 | GPR119 (0.50) | GPR119NPY5RCYP46A1NPC1GAA | |
| SCHEMBL6502064 | 0.78 | GPR119 (0.50) | GPR119NPY5RCYP46A1NPC1GAA | |
| SCHEMBL30663949 | 0.74 | GPR119 (0.53) | GPR119NOTUMCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL31516268 | 0.74 | NOTUM (0.71) | NOTUMCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4392645 | 0.74 | GPR119 (0.53) | GPR119NOTUMCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL21828535 | 0.74 | GPR119 (0.51) | GPR119NPY5RCHRNB2CHRNA4CHRNB4 | |
| SCHEMBL31401347 | 0.74 | KDM4E (0.61) | GPR119NPY5RKMT2ACHRNB2CHRNA4 | |
| SCHEMBL30664035 | 0.74 | KDM4E (0.61) | GPR119NPY5RKMT2ACHRNB2CHRNA4 | |
| SCHEMBL12988214 | 0.71 | CHRNB2 (0.51) | GPR119CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005019200-A2 | ARYL PIPERIDINE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-03-03 | — | — | WO | disclosed |