Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | MARK3 | P27448 | 1/20 | 0.35 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.35 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4149607 | 0.88 | PIM1 (0.37) | GPR119PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL2789678 | 0.85 | NR1H2 (0.38) | GPR119PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL16060936 | 0.83 | PIM1 (0.36) | GPR119PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL20864185 | 0.83 | FAAH (0.43) | GPR119PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL15874826 | 0.82 | TBXAS1 (0.46) | PIM1MARK3MAP4K2CAMK2BPIM3 | |
| SCHEMBL6555080 | 0.82 | PIM1 (0.35) | GPR119PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL7654635 | 0.76 | PIM1 (0.39) | GPR119PIM1MARK3MAP4K2CAMK2B | |
| SCHEMBL18536815 | 0.75 | CYP11B1 (0.48) | CYP11B2L3MBTL1CYP11B1 | |
| SCHEMBL406298 | 0.75 | ATM (0.38) | — | |
| SCHEMBL9516130 | 0.74 | PIM1 (0.38) | GPR119PIM1MARK3MAP4K2CAMK2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966446-A1 | BICYCLIC INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998034921-A1 | BICYCLIC INHIBITORS OF PROTEIN FARNESYL TRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1998-08-13 | — | — | WO | disclosed |