SCHEMBL8312870

SCHEMBL8312870

CCc1ccc(-c2ccc(C(=O)N(C)OC)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.49
ALDH1A1 P00352 3/20 0.47
TDP1 Q9NUW8 1/20 0.45
GPR119 Q8TDV5 1/20 0.45
HPGD P15428 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
MAPT P10636 2/20 0.44
RXRA P19793 2/20 0.44
RXRB P28702 2/20 0.44
PLK1 P53350 1/20 0.43
PIK3CA P42336 1/20 0.43
MTOR P42345 1/20 0.43
MCHR1 Q99705 4/20 0.43
HSD17B2 P37059 1/20 0.41
BCL2 P10415 1/20 0.41
CYP2D6 P10635 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8429380 0.95 MLYCD (0.53) MLYCDALDH1A1TDP1GPR119HPGD
SCHEMBL9154730 0.85 MLYCD (0.48) MLYCDALDH1A1GPR119HPGDMAPT
SCHEMBL8046453 0.85 HRH3 (0.55) MLYCDGPR119MCHR1HSD17B2
SCHEMBL25146746 0.83 FAAH (0.58) MLYCD
SCHEMBL8115787 0.81 ESR1 (0.54) MLYCDALDH1A1MAPTPLK1
SCHEMBL12982112 0.81 MLYCD (0.53) MLYCDALDH1A1GPR119HPGDSMN1; SMN2
SCHEMBL4449884 0.81 MAPT (0.56) MLYCDALDH1A1HPGDSMN1; SMN2MAPT
SCHEMBL9152657 0.81 MLYCD (0.53) MLYCDALDH1A1TDP1HPGDSMN1; SMN2
SCHEMBL13670740 0.79 MEN1 (0.51) MLYCDALDH1A1TDP1HPGDSMN1; SMN2
SCHEMBL4841742 0.79 MLYCD (0.51) MLYCDALDH1A1HPGDSMN1; SMN2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021119249-A1 CYCLOPHILIN D INHIBITORS AND USES THEREOF THE BROAD INSTITUTE, INC. (US) 2021-06-17 WO disclosed
EP-0948257-A4 TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO INC (US) 1999-12-29 EP disclosed
EP-0948257-A1 TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE Merck & Co., Inc. (US) 1999-10-13 EP disclosed
US-5955480-A GLUCAGON RECEPTOR ANTAGONISTS, CYTOKINE INHIBITORS MERCK & CO., INC. (US) 1999-09-21 US disclosed
WO-1998021957-A1 TRIARYL SUBSTITUTED IMIDAZOLES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHODS OF USE MERCK & CO., INC. (US) 1998-05-28 WO disclosed