Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 3/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312879 | 1.00 | MAPT (0.32) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL8311619 | 0.89 | MAPT (0.44) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL8311200 | 0.89 | MAPT (0.44) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL8313159 | 0.86 | MAPT (0.45) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL8313155 | 0.86 | MAPT (0.45) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8454357 | 0.85 | MAPT (0.47) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8454360 | 0.85 | MAPT (0.47) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL8316367 | 0.83 | PTGS2 (0.41) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL8316370 | 0.83 | PTGS2 (0.41) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 | |
| SCHEMBL8316364 | 0.83 | PTGS2 (0.41) | MAPTKDM4EHSD17B10TP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | claimed |
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| EP-0351856-A2 | Thiazolo[5,4-b]azepine compounds | Takeda Chemical Industries, Ltd. (JP) | 1990-01-24 | — | — | EP | disclosed |