Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | LYN | P07948 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | CSK | P41240 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316370 | 1.00 | PTGS2 (0.41) | PTGS2PTGS1NFE2L2TRPA1ALOX5 | |
| SCHEMBL8316364 | 1.00 | PTGS2 (0.41) | PTGS2PTGS1NFE2L2TRPA1ALOX5 | |
| Oxalic Acid SCHEMBL8315183 | 0.94 | PTGS2 (0.39) | PTGS2PTGS1NFE2L2TRPA1ALOX5 | |
| Oxalic Acid SCHEMBL8315178 | 0.94 | PTGS2 (0.39) | PTGS2PTGS1NFE2L2TRPA1ALOX5 | |
| SCHEMBL8311619 | 0.90 | MAPT (0.44) | NFE2L2CYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL8311200 | 0.90 | MAPT (0.44) | NFE2L2CYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL8313159 | 0.86 | MAPT (0.45) | NFE2L2CYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL8313155 | 0.86 | MAPT (0.45) | NFE2L2CYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL8317000 | 0.85 | CYP1A1 (0.44) | NFE2L2CYP1A2CYP1A1CYP1B1CYP19A1 | |
| SCHEMBL8316999 | 0.85 | CYP1A1 (0.44) | NFE2L2CYP1A2CYP1A1CYP1B1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0351856-B1 | Thiazolo[5,4-b]azepine compounds | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-09-15 | — | — | EP | disclosed |
| US-5300639-A | 2-oxo-3-carbonylamino-substituted azepine intermediates; lipoperoxide formation inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-05 | — | — | US | disclosed |
| US-5118806-A | Enzyme inhibitor for lipoxygenase; useful for treating cancer, hepatic diseases, inflammation, cerebrovascular diseases | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| US-4956360-A | LIPOPEROXIDE INHIBITORS, ENZYME INHIBITORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1990-09-11 | — | — | US | disclosed |