Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8313155 | 1.00 | MAPT (0.45) | MAPTKDM4EHSD17B10NFE2L2CYP1A1 | |
| Hydrochloric Acid SCHEMBL8454357 | 0.99 | MAPT (0.47) | MAPTKDM4EHSD17B10NFE2L2CYP1A1 | |
| Hydrochloric Acid SCHEMBL8454360 | 0.99 | MAPT (0.47) | MAPTKDM4EHSD17B10NFE2L2CYP1A1 | |
| SCHEMBL8311619 | 0.97 | MAPT (0.44) | MAPTKDM4EHSD17B10NFE2L2CYP1A1 | |
| SCHEMBL8311200 | 0.97 | MAPT (0.44) | MAPTKDM4EHSD17B10NFE2L2CYP1A1 | |
| SCHEMBL8316367 | 0.86 | PTGS2 (0.41) | MAPTKDM4EHSD17B10NFE2L2CYP1A1 | |
| SCHEMBL8316364 | 0.86 | PTGS2 (0.41) | MAPTKDM4EHSD17B10NFE2L2CYP1A1 | |
| SCHEMBL8316370 | 0.86 | PTGS2 (0.41) | MAPTKDM4EHSD17B10NFE2L2CYP1A1 | |
| SCHEMBL8312878 | 0.86 | MAPT (0.32) | MAPTKDM4EHSD17B10NFE2L2CYP1A2 | |
| SCHEMBL8312879 | 0.86 | MAPT (0.32) | MAPTKDM4EHSD17B10NFE2L2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0443588-B1 | Condensed thiazole compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-23 | — | — | EP | claimed |
| US-5153201-A | Inhibitors of lipoperoxide and lipoxygenase; antiischemic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-06 | — | — | US | claimed |
| EP-0443588-A1 | Condensed thiazole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | claimed |
| EP-0443588-B1 | Condensed thiazole compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5153201-A | Inhibitors of lipoperoxide and lipoxygenase; antiischemic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-10-06 | — | — | US | disclosed |
| EP-0443588-A1 | Condensed thiazole compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-08-28 | — | — | EP | disclosed |