Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.40 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316915 | 0.94 | TSHR (0.46) | KMT2ATSHRSIGMAR1PDE3BPDE3A | |
| SCHEMBL8312715 | 0.88 | KMT2A (0.40) | KMT2ATSHRERCC1ERCC4SIGMAR1 | |
| SCHEMBL8314804 | 0.85 | SIGMAR1 (0.43) | KMT2ATSHRSIGMAR1PDE3BPDE3A | |
| SCHEMBL8318855 | 0.84 | KMT2A (0.40) | KMT2ATSHRERCC1ERCC4SIGMAR1 | |
| SCHEMBL8318856 | 0.83 | KMT2A (0.40) | KMT2ATSHRERCC1ERCC4SIGMAR1 | |
| SCHEMBL8312314 | 0.83 | SMN1; SMN2 (0.38) | KMT2ATSHRSMN1; SMN2P2RX7CYP3A4 | |
| SCHEMBL8877083 | 0.83 | TSHR (0.45) | KMT2ATSHRERCC1ERCC4SIGMAR1 | |
| SCHEMBL8316358 | 0.82 | KMT2A (0.40) | KMT2ATSHRERCC1ERCC4SIGMAR1 | |
| SCHEMBL8318010 | 0.81 | KMT2A (0.47) | KMT2ATSHRSIGMAR1SMN1; SMN2CYP3A4 | |
| SCHEMBL9538321 | 0.81 | SIGMAR1 (0.49) | KMT2ATSHRSIGMAR1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0501129-B1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1999-07-14 | — | — | EP | disclosed |
| EP-0501129-A1 | Substituted bicyclic 3-arylpyrrolidin-2,4-dion derivatives | BAYER AG (DE) | 1992-09-02 | — | — | EP | disclosed |