Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 4/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315518 | 0.95 | OPRM1 (0.46) | OPRM1OPRD1OPRK1KCNH2ABCB11 | |
| SCHEMBL8314573 | 0.85 | OPRD1 (0.58) | OPRM1OPRD1OPRK1KCNH2ABCB11 | |
| SCHEMBL2457390 | 0.84 | OPRD1 (0.61) | OPRM1OPRD1OPRK1KCNH2ABCB11 | |
| Bromide SCHEMBL10598951 | 0.82 | OPRD1 (0.59) | OPRM1OPRD1OPRK1KCNH2ABCB11 | |
| Hydrochloric Acid SCHEMBL7647391 | 0.82 | OPRD1 (0.59) | OPRM1OPRD1OPRK1KCNH2ABCB11 | |
| SCHEMBL13437760 | 0.80 | OPRM1 (0.56) | OPRM1OPRD1OPRK1LMNATP53 | |
| SCHEMBL10461671 | 0.77 | OPRM1 (0.67) | OPRM1OPRD1OPRK1KCNH2ABCB11 | |
| SCHEMBL10460871 | 0.77 | OPRD1 (0.65) | OPRM1OPRD1OPRK1KCNH2ABCB11 | |
| SCHEMBL9434960 | 0.76 | OPRD1 (0.57) | OPRM1OPRD1OPRK1KCNH2ABCB11 | |
| SCHEMBL22491524 | 0.75 | OPRM1 (0.50) | OPRM1OPRD1OPRK1KCNH2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |
| CN-1033327-C | Process for preparing tricyclotriazolo derivatives and their use | TORAY INDUSTRIES (JP) | 1996-11-20 | — | — | CN | disclosed |
| EP-0536419-A1 | TRICYCLIC TRIAZOLE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1993-04-14 | — | — | EP | disclosed |
| CN-1066849-A | Three ring triazolo derivatives, its Manufacturing approach and use | TORAY INDUSTRIES (JP) | 1992-12-09 | — | — | CN | disclosed |