Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312627 | 0.78 | DRD2 (0.81) | DRD2DRD4DRD3 | |
| SCHEMBL8317510 | 0.77 | DRD2 (0.64) | DRD2DRD4DRD3HTR1DHTR1B | |
| SCHEMBL8643128 | 0.77 | DRD2 (0.64) | DRD2DRD4DRD3HTR1DHTR1B | |
| SCHEMBL8314765 | 0.74 | DRD2 (0.68) | DRD2DRD4DRD3HTR1DHTR1B | |
| SCHEMBL5156793 | 0.73 | CRBN (0.51) | CRBNGAACYP1A2CYP2C19MEN1 | |
| SCHEMBL2115589 | 0.73 | CRBN (0.51) | CRBNGAACYP1A2CYP2C19MEN1 | |
| SCHEMBL2115582 | 0.73 | CRBN (0.51) | CRBNGAACYP1A2CYP2C19MEN1 | |
| SCHEMBL3035136 | 0.71 | DRD2 (0.37) | DRD2DRD4DRD3PKMGAA | |
| SCHEMBL5954233 | 0.71 | DRD2 (0.37) | DRD2DRD4DRD3PKMGAA | |
| SCHEMBL3039847 | 0.71 | DRD2 (0.37) | DRD2DRD4DRD3PKMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0771801-B1 | Chromane derivatives | AMERICAN HOME PROD (US) | 1999-03-03 | — | — | EP | disclosed |
| EP-0771801-A1 | Chromane derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |